Kratom, also known as Mitragyna Speciosa is a large tree native to Southeast Asia, predominantly found in Thailand, Indonesia, Malaysia. This plant belongs to the Rubiaceae family which is the same family as coffee tree.
A Study on 3-dehydromitragynine was carried out in 1986 by Ekkasit Kumainsita of the department of physiology-Faculty of science, PSU, Hat-Yai, Thailand. The research was a study on the fresh leaves of Kratom which led to the isolation of 3-dehydromitragynine through chemical transformations and spectral means. The findings of this scientific research were published in the phytochemistry volume 25-Issue 12, 1986, Pg 2910 to 2912. The objective of the study was to establish alkaloids present in Kratom. Apart from 3-dehydromitragynine, the study reported the presence of many more alkaloids.
A study in 1986 on evaluation of analgesia induced by Mitragynine, paracetamol and morphine in Mice. This study was conducted by S.Z Idid, M.M Shahimi and H. Yaacob to find out the antinociceptive ability of mitragynine in comparison to that of morphine and paracetamol. The findings of this study were published in phytochemistry Volume 25,-issue 12, 1986, pg 2910 to 2912. The researchers established that all the 3 materials produced notable analgesia. They concluded that kratom could possibly be a potential new analgesia that needed further study.
Journal of Ethnopharmacology has published a study in 1988 conducted by Colin J. Prast and Karl Jansen of the department of anatomy, university of Auckland Medical School. The aim of the study was to describe the main alkaloids in Mitragyna Speciosa. This study concluded that Kratom may be suitable for use as an antitussive, analgesic and a hypothermic agent. Furthermore, the study revealed that Kratom can be substituted naturally for methadone opiate addiction treatment.
A study on the long-term and acute effects of alkaloid extract of Kratom on food, water intake and body weight in rats. This study was carried in August 2004 by Ikram M. Saida of the Chemistry Department, University of Kebangsaan Malaysia and Peter J. Houghton of the Chelsea department of pharmacy, Kings College London. In the findings, the researchers discovered that acute administration of Kratom extract (about 45 to 50 mg/kg) resulted to decreased dependence on water and food intakes. Prolonged effects were realized when administration of the Kratom extract was done for two months consecutively. Furthermore, the long term administration led to weight loss. From these findings, the two researchers finalized by saying that Kratom might be of medicinal importance in the fight against obesity.
In 2006 pharmacological study of 7-Hydroxymitragynine extract from kratom was conducted by Kenjiro Matsumoto in 2006. The objective of this study was to establish the medicinal significance of Kratom as an orally active painkiller. The researcher studied the pharmacological-properties associated to 7-Hydroxymitragynine isolated from an ancient Thai Kratom plant to come up with a conclusion that this herb was viable for application as an oral pain killer.
A Study on the in vivo and in vitro effects of three different Kratom extracts was conducted in 2010 by Juzaili Aziz 1, Mohd Ikram Said-2, Mohd Nizam Mordi I, Sabariah Ismail 1, Sharif Mahsufi Mansor and Surash Ramanathan to investigate the effects of methanolic, total alkaloid extracts and aqueous ( 3 Kratom extracts) on Glutathione-transferase in rats. The aim of the research was to establish how Kratom extracts react with other herbs when given in-vivo (inside a living organism) & in-vitro (outside a living organism). The researchers established that Kratom extracts show a significant interaction with other herbs. They recommended that further research was needed to investigate its clinical significance in humans.
A Study on the total synthesis of Mitragynine and Analogues. This study was a Master Thesis done by Isabel Kerschgen in June 2012. The objective of this research was to demonstrate the medicinal value of Kratom. The researcher established that kratom may be a perfect treatment for coughing, muscle pain, hypertension and diarrhea. In addition, Kratom has proven to have strong analgesic effects similar to those of morphine and therefore it was suggested as a vital component in the cure of opiate addiction.
In conclusion, Mitragyna Speciosa has been used for centuries as a cure for various mental and physical ailments. These scientific studies act as evidence of great medicinal value attached to this ancient herb. Despite all the research done, much more is necessary before this plant can be applied in medicine. All the information provided is strictly for educational and informational purposes and according to botanical research. While Kratom (Mitragyna Speciosa) is recognized in many cultures, U.S. Food and Drug Administration (FDA) strictly prohibits internal use of this herb.